According to 21 U.S.C. § 812, Schedule I drugs have a high potential for abuse.  Additionally, Congress has deemed that the drug or other substance has no currently accepted medical use in treatment in the United States, and that there is a lack of accepted safety for use of the drug or other substance under medical supervision.

The drugs on Schedule I are:

(a) Unless specifically excepted or unless listed in another schedule, any of the following opiates, including their isomers, esters, ethers, salts, and salts of isomers, esters, and ethers, whenever the existence of such isomers, esters, ethers, and salts is possible within the specific chemical designation:
   (1) Acetylmethadol.
   (2) Allylprodine.
   (3) Alphacetylmathadol [Alphacetylmethadol].
   (4) Alphameprodine.
   (5) Alphamethadol.
   (6) Benzethidine.
   (7) Betacetylmethadol.
   (8) Betameprodine.
   (9) Betamethadol.
   (10) Betaprodine.
   (11) Clonitazene.
   (12) Dextromoramide.
   (13) Dextrorphan.
   (14) Diampromide.
   (15) Diethylthiambutene.
   (16) Dimenoxadol.
   (17) Dimepheptanol.
   (18) Dimethylthiambutene.
   (19) Dioxaphetyl butyrate.
   (20) Dipipanone.
   (21) Ethylmethylthiambutene.
   (22) Etonitazene.
   (23) Etoxeridine.
   (24) Furethidine.
   (25) Hydroxypethidine.
   (26) Ketobemidone.
   (27) Levomoramide.
   (28) Levophenacylmorphan.
   (29) Morpheridine.
   (30) Noracymethadol.
   (31) Norlevorphanol.
   (32) Normethadone.
   (33) Norpipanone.
   (34) Phenadoxone.
   (35) Phenampromide.
   (36) Phenomorphan.
   (37) Phenoperidine.
   (38) Piritramide.
   (39) Proheptazine.
   (40) Properidine.
   (41) Racemoramide.
   (42) Trimeperidine.
 
(b) Unless specifically excepted or unless listed in another schedule, any of the following opium derivatives, their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
   (1) Acetorphine.
   (2) Acetyldihydrocodeine.
   (3) Benzylmorphine.
   (4) Codeine methylbromide.
   (5) Codeine-N-Oxide.
   (6) Cyprenorphine.
   (7) Desomorphine.
   (8) Dihydromorphine.
   (9) Etorphine.
   (10) Heroin.
   (11) Hydromorphinol.
   (12) Methyldesorphine.
   (13) Methylhydromorphine.
   (14) Morphine methylbromide.
   (15) Morphine methylsulfonate.
   (16) Morphine-N-Oxide.
   (17) Myrophine.
   (18) Nicocodeine.
   (19) Nicomorphine.
   (20) Normorphine.
   (21) Pholcodine.
   (22) Thebacon.
 
(c) Unless specifically excepted or unless listed in another schedule, any material, compound, mixture, or preparation, which contains any quantity of the following hallucinogenic substances, or which contains any of their salts, isomers, and salts of isomers whenever the existence of such salts, isomers, and salts of isomers is possible within the specific chemical designation:
   (1) 3, 4-methylenedioxy amphetamine.
   (2) 5-methoxy-3, 4-methylenedioxy amphetamine
   (3) 3, 4, 5-trimethoxy amphetamine.
   (4) Bufotenine.
   (5) Diethyltryptamine.
   (6) Dimethyltryptamine.
   (7) 4-methyl-2, 5-dimethoxyamphetamine.
   (8) Ibogaine.
   (9) Lysergic acid diethylamide.
   (10) Marihuana.
   (11) Mescaline.
   (12) Peyote.
   (13) N-ethyl-3-piperidyl benzilate.
   (14) N-methyl-3-piperidyl benzilate.
   (15) Psilocybin.
   (16) Psilocyn.
   (17) Tetrahydrocannabinols.